( Siegel et al., 2019) A small proportion of breast cancers have an inheritable genetic basis. In the US, breast cancer is the second most diagnosed cancer, and is the second leading cause of cancer mortality. The utilization of testing and corresponding test results differed significantly across races/ethnicities, suggestive of a divergent application of the same testing criteria. Between 20, increasing use of BRCA testing for cancer prevention and treatment occurred, correlating to the observed decreasing documented positive test rate. In 2015–2017, women with positive test results were less likely to be non–Hispanic Whites, cancer patients, or living in the Northeast or an area with average household income ≥$50,000. From 2007 to 2017, decreasing trends in the rates of documented positive results were observed among all three age groups (18–39, 40–54, and 55–65 years largest in 40–54 group). Positive results indicated the presence of pathogenic variantss. Using Clinformatics© Data Mart (CDM) Electronic Health Records, we included 223,211 women 18–65 years old with documented BRCA testing results from –. The aim of this study was to assess trends in BRCA test rates and results among adult women aged 18 to 65 in the US between 20. Since the 1990 s discovery of BRCA1 and BRCA2 pathogenic variants in breast or ovarian cancer patients, genetic testing has been recommended as part of a targeted, individualized approach for cancer prevention and treatment in eligible individuals.
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